There is more at work here than just size. Factors to consider for heat transfer to the air in the plenum are cold air return temp, humidity, air speed, water flow in GPM, inlet water temp, and differential pressure drop across the exchanger for both air and water.
Exchangers are rated for btu delivery to the air at a standard air speed with a standard delta T temp drop in the water - usually "X" btu at 1200 cfm with 20* drop in water temp.
There are calculators for this; you input your numbers and get an idea what type of flow you need, how many passes in the exchanger, etc.
Also, not all exchangers are equal - you get what you pay for here, so it is worth the time to do the math and get the best exchanger you can afford.
The exchanger should be in the plenum after the burner and fan, and above the A/C coil if installed. Make sure it is accessible for cleaning, as the fins will collect very small dust particles even with the good filters (I use 3M Filtrete).
There is a wealth of information on this subject here:
http://www.**********/econtent/index.php/forums/viewforum/21/
I hope this helps!