the venom from Brown recluse spider bites is an enzyme that liqufies tissue. Get her to the ER asap as it spreads quickly, Have them call the CDC if they do not know how to handel it. This is not something to be messing around with home remedies ( although some do help). Even if it turns out that it is a tick bite, considering what some of them carry, this is your best move. A regimene of antibiotics is part of the perscription. Surgery is sometimes required to minimize the impact. Don't mean to be an alarmest but it can be very serious.