My cousin once shot a Buck with his 300 Win Mag loaded with 110 gr bullets, he thought it would drop in it's tracks, but instead the bullet blew up on the shoulder and the Buck went 4 ever.
What SVK said makes a lot of sense.
If you hunt in open fields or mature forests where there is not a lot of hunting pressure, I'm sure you are less concerned about things that concern me.
My property was devastated by a tornado a couple of decades ago. When hunting season starts, the Bucks all go into the thick cover, and you are not likely to get a shot at one standing still. If you are not going to shoot at one that is in heavy brush, you are not going to get a deer. That said, i try to find the clearest shot possible, but often you can't see all the small stuff.
While no bullet is immune to brush, some are dramatically more effected by it than others. Generally, high speed, light weight, soft bullets are the worst. As an example, Winchester 130 grain factory ammo ... I will never use it again. It deflects wildly on very small brush, and it cost me a deer! My subsequent ballistic testing revealed that the bullet opens instantly and in a not uniform mushroom (the large mushroom is slanted to the side).
I don't have the amount of "killing" experience that some on this site have, but that does not mean that my ballistic testing does not have relevance to determining what bullets/loads/calibers are or are not suited for the conditions I encounter. Because I often spend a lot of time finding game, it is important that my firearm perform as well as possible when I do find it.
Since 243, 270, 30, and 338 diameter bullet all generally use a 1-10 twist, I have to believe the gyroscopic stability of the larger diameter bullets is better. Keep in mind that circumference increases far faster than diameter. That is why larger diameter bullets will also often provide a better blood trail and faster kills.