Fireblight, that sucks. We had an out-break years ago in one of our pear blocks. Pruning will work, but try to keep the infected limbs from touching the none infected areas. Haul it far away making sure it don't rub other trees when your driving out the rows and cover it up, till it dries up. Do not burn it, rite away, this can spread it, even more. We used to spray cooper sulfide (I think that's it) on them also.
Bad news is; We ended-up cutting down over a hundred prime (8yr old trees) bartletts to the ground before we was able to get it under control. Devistated the whole block. This was about 15 years ago.
This is from the best of my memory. Good luck, and let us know how your making out.