I've been running 285/70-17 Goodyear MT/R's on my 1995 4wd 3/4 ton 454 gas Suburban since 2005. Its the backup vehicle that only sees duty when we get a big snow or something needs to be hauled, but in that time I have put around 25,000 miles on it and the tires are around 50% tread. Without question these tires do humm going down the highway, but I do manage to squeeze around 11mpg out of it (not too bad IMHO) keeping my speed reasonable. In comparison I had BFG A/T's on a different truck (daily driver) and they were done in 30,000 miles after being religious about rotating them every 6,000 miles. Every once in awhile I start to think that I run the MT/R's just for show, but then I need to back a trailer through 24" of snow or something similar, and I remember that those tires have a specific purpose and have always come through for me when I have needed them. When it comes time to replace them I will likely put a similar tire on.
Also, my Father has had great luck running BFG Commercial T/A Tractions on his F-350. Depending on size availability this may be a choice worth looking at. As I recall he has gotten around 60,000 miles out of fronts and 80,000 miles out of rears on that truck.