Heya Cantdog,
Well, to my mind, because we're not talking about smooth continuous flow in a saw engine (macs, btw, are generally piston ported.... The homies were reedies for the most part... But that's not really relevant). It's not so much flow as it is gulps. The piston goes towards TDC, opens the piston port, or the reed valves open on low cc pressure. A gulp of air is taken in thru the carburetor. The intake tract closes as the engine continues to turn, and the charge is now trapped, in the crankcase, and is stirred in place, while being compressed (secondary compression) by the falling piston... Then finally, the exhaust ports, and then transfer ports open, the charge suddenly rushes into the cylinder.... From a standstill, effectively... Then it's trapped again, compressed, burned, exhaled.
No matter the intake arrangement, piston ported, reed, rotary, the transfer ports and exhaust ports in the cylinder are gonna be a variation on Schnurle loop-scavenging porting.... It should make no difference the orientation of the cylinder.
I'm sure there are practical considerations where it may make a small difference, but airflow thru the engine isn't the major reason for the evolution.
J